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How much Fenbendazole should be taken?



The amount of Fenbendazole intake each day can change based on the patient’s health and any additional medicines or treatments they may be taking.

It is essential to chat with a qualified medical provider who is knowledgeable in traditional chemotherapy and the combination of different cancer therapies, as well as know how to navigate the potential adverse effects of taking many medicines or chemicals together. This consultation is key if you would like to mix chemotherapy, natural elements, dietary supplements, or other medicines with Fenbendazole, and also verify if Fenbendazole is right for you.

Keep Fenbendazole at a temperature lower than 25 degrees Celisus to avoid damage from the sun. This applies for pills, powder and capsules as well. It is difficult to pinpoint what side effects could appear in humans from consumption of an average or high dose of Fenbendazole due to its lack of history in human consumption. These estimates become less certain if Fenbendazole is being taken with other drugs. Toxicity, genotoxicity, and carcinogenicity are still unknown.

When ingested orally, Fenbendazole appears to be minimally toxic according to tests performed with rodents, as no acute exposure limit has been determined. More insight into the safety of consuming this substance is provided by human data, which suggests that 500 mg per individual is mild with no adverse effects, while 2000 mg per person did not produce any negative reaction. In addition, studies conducted by the European Medicine Agency have concluded that Fenbendazole is not genotoxic, however a two-year study in mice has indicated its potential for carcinogenicity.


The following side effects have been reported: Jaundice (very uncommon), Diarrhea (uncommon), Skin itching (very uncommon), Vomiting (uncommon), Injury (extremely uncommon), and changes in Metabolism.

After consuming Fenbendazole, the drug is subjected to two metabolic processes in the body – oxidation and hydroxylation. The first of these processes is supported by CYP2J2 and CTP2C19 liver enzymes, transforming Fenbendazole into hydroxytenbendazole. The sulfide group is then oxidized through the CYP3A and flavin-containing monooxygenase enzymes in the liver, creating oxfendazole with its cancer-fighting and parasite-destroying capabilities.

The interesting thing about this process is that Fenbendazole can act as both a drug and a prodrug, meaning it is able to produce another active medication. As it has low bioavailability however, only a small amount of it is able to be absorbed through the gastrointestinal tract, and the remainder is excreted through the anus. Additionally, the enzyme that aids in the metabolizing of Fenbendazole, CTP2C19, is the same enzyme that helps in the metabolism of other medications such as astemizole, mesoridazine, apixaban, tamoxifen, ebasite, cyclosporine, and thioridazine. – Prior to deciding to take any of these drugs, in association with an increased amount of Fenbendazole, it is advised to speak with a doctor to acquire more information and direction related to the interaction between Febendazole and the other medications. Make sure to research the probability of a side effect occurring, as well as the potential for an elevation.

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